Basic Science

Clotting profile assessment

Interpretation of coagulation and clotting profiles, including tests used pre-operatively

3 questions 1 source pages

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Q1How are the intrinsic and extrinsic clotting pathways activated?▸

Intimal tear -> exposed collagen -> activates the intrinsic pathway
Damage of vessels -> exposes extravascular tissue -> activates the extrinsic pathway

Q2How do LMWH/heparin work?▸

Q3Match dabigatran, rivaroxaban and warfarin to their targets.▸

Dabigatran: inhibits factor 2 (Bi = 2)
Rivaroxaban: factor 10a inhibitor (Xa = 10a)
Warfarin: inhibits factors 2, 7, 9, 10 via vitamin K epoxide reductase inhibition

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