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Arthritis

Arthritis - classification and gout

Arthritis definitions and systemic monosodium urate crystal deposition disease

10 questions 2 source pages

Images appear with the first question taken from each source page — tap a question to open it.

10 questions
Q1What is the named condition on this section?▸
  • Arthritis
  • No speaker notes were provided, so further details are not in the notes
Q2What are the key features of arthritis shown on this section?▸
  • Not covered in the speaker notes
  • Only the source image is available as a source
Q3What is the definition and metabolic pathway of gout?▸
  • Systemic metabolic disease of monosodium urate crystal deposition
  • Purine -> hypoxanthine -> xanthine -> uric acid
  • Xanthine oxidase acts in the 2nd and 3rd steps
Q4What is primary gout?▸
  • Idiopathic disorder of nucleic acid metabolism
  • Leads to hyperuricaemia and crystal deposition in joints
Q5What is secondary gout and what causes it?▸
  • Secondary to increased purine production (high metabolic turnover) or decreased excretion
  • Causes: psoriasis, haemolytic anaemia, leukaemia, chemotherapy, renal impairment
Q6How is gout diagnosed?▸
  • Joint aspiration with examination of the fluid
  • Strongly negatively birefringent, thin, tapered, needle-shaped intracellular crystals
Q7What is the mechanism of colchicine in gout?▸
  • Affects microtubule formation
  • Inhibits neutrophils
Q8What is the mechanism of NSAIDs in gout?▸
  • Inhibit COX
  • Decrease prostaglandin formation and inflammation
Q9Which drugs inhibit xanthine oxidase in gout?▸
  • Allopurinol
  • Febuxostat
Q10What is the role of probenecid in gout?▸
  • Probenecid is a uricosuric agent
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